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Contents
- Front matter
  - Quick Reference Material
  - Preface to the third edition
  - Preface to the second edition
  - Preface to the first edition
  - Foreword to the first edition
  - Acknowledgements
  - Contributors
  - Symbols and abbreviations
- Chapter 1 Clinical approach
  - Chapter 1 Clinical approach
  - History taking in patients with haematological disease
  - Physical examination
  - Splenomegaly
  - Lymphadenopathy
  - Unexplained anaemia
  - Patient with elevated haemoglobin
  - Elevated WBC
  - Reduced WBC
  - Elevated platelet count
  - Reduced platelet count
  - Easy bruising
  - Recurrent thromboembolism
  - Pathological fracture
  - Raised ESR
  - Serum or urine paraprotein
  - Anaemia in pregnancy
  - Thrombocytopenia in pregnancy
  - Prolonged bleeding after surgery
  - Positive sickle test (HbS solubility test)
- Chapter 2 Red cell disorders
  - Chapter 2 Red cell disorders
  - The peripheral blood film in anaemias
  - Anaemia in renal disease
  - Anaemia in endocrine disease
  - Anaemia in joint disease
  - Anaemia in gastrointestinal disease
  - Anaemia in liver disease
  - Iron (Fe) deficiency anaemia
  - Vitamin B₁₂ deficiency
  - Folate deficiency
  - Other causes of megaloblastic anaemia
  - Anaemia in other deficiency states
  - Haemolytic syndromes
  - Genetic control of haemoglobin production
  - Sickling disorders
  - HbS—new therapies
  - Sickle cell trait (HbAS)
  - Other sickling disorders
  - Other haemoglobinopathies
  - Unstable haemoglobins
  - Thalassaemias
  - α thalassaemia
  - β thalassaemia
  - Other thalassaemias
  - Hereditary persistence of fetal haemoglobin
  - Hb patterns in haemoglobin disorders
  - Non-immune haemolysis
  - Hereditary spherocytosis
  - Hereditary elliptocytosis
  - Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  - Pyruvate kinase (PK) deficiency
  - Other red cell enzymopathies
  - Drug-induced haemolytic anaemia
  - Methaemoglobinaemia
  - Microangiopathic haemolytic anaemia (MAHA)
  - Acanthocytosis
  - Autoimmune haemolytic anaemia
  - Cold haemagglutinin disease (CHAD)
  - Leucoerythroblastic anaemia
  - Aplastic anaemia
  - Paroxysmal nocturnal haemoglobinuria
  - Pure red cell aplasia
  - Iron (Fe) overload
  - Transfusion haemosiderosis
- Chapter 3 White blood cell abnormalities
  - Chapter 3 White blood cell abnormalities
  - Neutrophilia
  - Neutropenia
  - Lymphocytosis and lymphopenia
  - Eosinophilia
  - Basophilia and basopenia
  - Monocytosis and monocytopenia
  - Mononucleosis syndromes
- Chapter 4 Leukaemia
  - Chapter 4 Leukaemia
  - Acute myeloblastic leukaemia (AML)
  - Acute lymphoblastic leukaemia (ALL)
  - Chronic myeloid leukaemia (CML)
  - Chronic lymphocytic leukaemia (B-CLL)
  - Cell markers in chronic lymphoproliferative disorders
  - Prolymphocytic leukaemia (PLL)
  - Hairy cell leukaemia and variant
  - Splenic marginal zone lymphoma (SMZL)
  - Mantle cell lymphoma (MCL)
  - Large granular lymphocyte leukaemia (LGLL)
  - Adult T-cell leukaemia-lymphoma (ATL)
  - Sézary syndrome (SS)
- Chapter 5 Lymphoma
  - Chapter 5 Lymphoma
  - Non-Hodgkin lymphoma (NHL)
  - Indolent lymphoma
  - Treatment of indolent lymphoma
  - Aggressive lymphomas
  - Initial treatment of aggressive lymphomas
  - CNS lymphoma
  - Hodgkin lymphoma (HL, Hodgkin’s disease)
- Chapter 6 Myelodysplasia
  - Chapter 6 Myelodysplasia
  - Myelodysplastic syndromes (MDS)
  - Classification
  - Clinical features of MDS
  - Diagnostic criteria of MDS
  - Prognostic factors in MDS
  - Clinical variants of MDS
  - Management of MDS
  - Response criteria
  - Myelodysplastic/myeloproliferative diseases (MDS/MPD)
- Chapter 7 Myeloproliferative neoplasms
  - Chapter 7 Myeloproliferative neoplasms
  - Myeloproliferative neoplasms (MPNs)
  - Pathogenesis of the MPNs
  - Polycythaemia vera (PV)
  - Natural history of PV
  - Management of PV
  - Secondary erythrocytosis
  - Relative erythrocytosis (RE)
  - Idiopathic erythrocytosis (IE)
  - Essential thrombocythaemia (ET)
  - Reactive thrombocytosis (RT)
  - Primary myelofibrosis (PMF)
  - Chronic neutrophilic leukaemia (CNL)
  - Chronic eosinophilic leukaemia (CEL) and idiopathic hypereosinophilic syndrome (HES)
  - Mast cell disease (mastocytosis)
  - Systemic mastocytosis (SM)
  - MPNs-unclassifiable (MPN-U)
- Chapter 8 Paraproteinaemias
  - Chapter 8 Paraproteinaemias
  - Paraproteinaemias
  - Monoclonal gammopathy of undetermined significance (MGUS)
  - Smouldering multiple myeloma (syn. asymptomatic myeloma)
  - Multiple myeloma (MM)
  - Variant forms of myeloma
  - Cryoglobulinaemia
  - POEMS syndrome
  - Plasmacytoma
  - Waldenström macroglobulinaemia (WM)
  - Heavy chain disease (HCD)
  - AL (1° systemic) amyloidosis
- Chapter 9 Haematopoietic stem cell transplantation (SCT)
  - Chapter 9 Haematopoietic stem cell transplantation (SCT)
  - Haemopoietic stem cell transplantation (SCT)
  - Indications for haemopoietic SCT
  - Allogeneic SCT
  - Autologous STC
  - Investigations for BMT/PBSCT
  - Pretransplant investigation of donors
  - Bone marrow harvesting
  - Peripheral blood stem cell mobilization and harvesting
  - Microbiological screening for stem cell cryopreservation
  - Stem cell transplant conditioning regimens
  - Infusion of cryopreserved stem cells
  - Infusion of fresh non-cryopreserved stem cells
  - Blood product support for SCT
  - GvHD prophylaxis
  - Acute GvHD
  - Chronic GvHD
  - Veno-occlusive disease (syn. sinusoidal obstruction syndrome)
  - Invasive fungal infections and antifungal therapy
  - CMV prophylaxis and treatment
  - Post-transplant vaccination programme
  - Treatment of relapse post-allogeneic SCT
  - Discharge and follow-up
- Chapter 10 Haemostasis and thrombosis
  - Chapter 10 Haemostasis and thrombosis
  - Assessing haemostasis
  - The coagulation system
  - Laboratory tests
  - Platelets
  - Bleeding
  - Bleeding: laboratory investigations
  - Bleeding: therapeutic products
  - von Willebrand disease (vWD)
  - Haemophilia A and B
  - Rare congenital coagulation disorders
  - Congenital thrombocytopenias
  - Congenital platelet function defects
  - Congenital vascular disorders
  - Haemorrhagic disease of the newborn
  - Thrombocytopenia (acquired)
  - Specific thrombocytopenic syndromes
  - Disseminated intravascular coagulation (DIC)
  - Anticoagulant drug therapy
  - Liver disease
  - Renal disease
  - Acquired anticoagulants and inhibitors
  - Treatment of spontaneous FVIII inhibitor
  - Acquired disorders of platelet function
  - Henoch–Schönlein purpura
  - Peri-operative bleeding and massive blood loss
  - Massive blood loss
  - Heparin
  - Heparin induced thrombocytopenia/ with thrombosis (HIT/T)
  - Oral anticoagulant therapy (warfarin, VKAs)
  - Thrombosis
  - Risk assessment and thromboprophylaxis
  - Example of VTE risk assessment
  - Heritable thrombophilia
  - Acquired thrombophilia
  - Thrombotic thrombocytopenic purpura (TTP)
  - Haemolytic uraemic syndrome (HUS)
  - Heparin-induced thrombocytopenia (HIT)
- Chapter 11 Immunodeficiency
  - Chapter 11 Immunodeficiency
  - Congenital immunodeficiency syndromes
  - Acquired immune deficiencies
  - HIV infection and AIDS
  - Therapy of HIV infection
- Chapter 12 Paediatric haematology
  - Chapter 12 Paediatric haematology
  - Blood counts in children
  - Red cell transfusion and blood component therapy—special considerations in neonates and children
  - Polycythaemia in newborn and childhood
  - Neonatal anaemia
  - Anaemia of prematurity
  - Haemolytic anaemia in the neonate
  - Congenital red cell defects
  - Acquired red cell defects
  - Haemolytic disease of the newborn (HDN)
  - Hyperbilirubinaemia
  - Neonatal haemostasis
  - Neonatal alloimmune thrombocytopenia (NAIT)
  - Congenital dyserythropoietic anaemias
  - Congenital red cell aplasia
  - Acquired red cell aplasia
  - Fanconi anaemia (FA)
  - Rare congenital marrow failure syndromes
  - Neutropenia in childhood
  - Disorders of neutrophil function
  - Childhood immune (idiopathic) thrombocytopenic purpura (ITP)
  - Haemolytic uraemic syndrome (HUS)
  - Childhood cancer and malignant blood disorders
  - Childhood lymphoblastic leukaemia
  - Childhood lymphomas
  - Childhood acute myeloid leukaemia (AML)
  - Childhood myelodysplastic syndromes and chronic leukaemias
  - Histiocytic syndromes
  - Haematological effects of systemic disease in children
- Chapter 13 Haematological emergencies
  - Chapter 13 Haematological emergencies
  - Septic shock/neutropenic fever
  - Transfusion reactions
  - Immediate-type hypersensitivity reactions
  - Febrile transfusion reactions
  - Delayed transfusion reaction
  - Bacterial contamination of blood products
  - Post-transfusion purpura
  - Hypercalcaemia
  - Hyperviscosity
  - Disseminated intravascular coagulation (DIC)
  - Overdosage of thrombolytic therapy
  - Heparin overdosage
  - Heparin-induced thrombocytopenia (HIT)
  - Warfarin overdosage
  - Massive blood transfusion
  - Paraparesis/spinal collapse
  - Leucostasis
  - Thrombotic thrombocytopenic purpura
  - Sickle crisis
- Chapter 14 Supportive care
  - Chapter 14 Supportive care
  - Quality of life
  - Pain management
  - Psychological support
- chapter 15 Protocols and procedures
  - chapter 15 Protocols and procedures
  - Acute leukaemia—investigations
  - Platelet storage and administration
  - Platelet reactions and refractoriness
  - Prophylactic regimen for neutropenic patients
  - Guidelines for use of IV antibiotics in neutropenic patients
  - Treatment of neutropenic sepsis when source unknown
  - Treatment of neutropenic sepsis when source known/suspected
  - Prophylaxis for patients treated with purine analogues
  - Tumour lysis syndrome (TLS)
  - Management of chronic bone marrow failure
  - Venepuncture
  - Venesection
  - Tunnelled central venous catheters
  - Bone marrow examination
  - Administration of chemotherapy
  - Antiemetics for chemotherapy
  - Intrathecal chemotherapy
  - Management of extravasation
  - Specific procedures after extravasation of cytotoxics commonly used in haematology
  - Splenectomy
  - Plasma exchange (plasmapheresis)
  - Leucapheresis
  - Anticoagulation therapy—heparin
  - Oral anticoagulation
  - Management of needlestick injuries
  - Chemotherapy protocols: ABVD
  - BEACOPP & escalated BEACOPP
  - BEAM
  - CHOP 21 & CHOP 14
  - ChlVPP
  - CODOX-M/IVAC
  - CTD & CTDa
  - DHAP ± R
  - EPOCH & DA-EPOCH ± R
  - ESHAP ± R
  - FC ± R
  - FMD ± R (FND ± R)
  - Hyper-CVAD ± R / MA± R
  - ICE ± R
  - MCP ± R
  - MINE
  - Mini-BEAM ± R
  - R-CHOP
  - R-CVP & CVP
  - Rituximab
  - Stanford V
  - VAPEC-B
- Chapter 16 Haematological investigations
  - Chapter 16 Haematological investigations
  - Full blood count
  - Blood film
  - Plasma viscosity
  - ESR
  - Haematinic assays
  - Haemoglobin electrophoresis
  - Haptoglobin
  - Schumm’s test
  - Kleihauer test
  - Reticulocytes
  - Urinary haemosiderin
  - Ham’s test
  - Immunophenotyping
  - Cytogenetics
  - Human leucocyte antigen (HLA) typing
- Chapter 17 Blood transfusion
  - Chapter 17 Blood transfusion
  - Introduction
  - Using the blood transfusion laboratory
  - Transfusion of red blood cells
  - Platelet transfusion
  - Fresh frozen plasma (FFP)
  - Cryoprecipitate
  - Intravenous immunoglobulin (IVIg)
  - Transfusion transmitted infections (TTI)
  - TRALI and TA-GVHD
  - Irradiated and CMV-negative blood products
  - Autologous blood transfusion
  - Maximum surgical blood ordering schedule (MSBOS)
  - Jehovah’s Witnesses
- Chapter 18 Phone numbers and addresses
  - Chapter 18 Phone numbers and addresses
  - American Society of Hematology
  - Birmingham Clinical Trials Unit (BCTU)
  - British Society for Haematology
  - CancerBACUP
  - CTSU
  - European Hematology Association
  - Leukaemia Research Fund (LRF)
  - Medical Research Council
  - National Cancer Research Network
  - Northern and Yorkshire Clinical Trials and Research Unit
- Chapter 19 Haematology online
  - Chapter 19 Haematology online
  - Haematology online
- Chapter 20 Charts and nomograms
  - Chapter 20 Charts and nomograms
  - Karnofsky performance status
  - WHO/ECOG performance status
  - WHO haematological toxicity scale
  - Body surface area nomogram
  - Gentamicin dosage nomogram
  - The Sokal Score for CML prognostic groups
- Chapter 21 Normal ranges
  - Chapter 21 Normal ranges
  - Adult normal ranges
  - Paediatric normal ranges
- End matter
  - Coloured Plates
- Index
  - Index

3rd edition

The Oxford Handbook of Clinical Haematology continues to provide the core knowledge needed in clinical practice for the diagnosis and management of patients with disorders of the blood. Major advances in the specialty have been reflected in this thoroughly revised content. Differential diagnoses, relevant investigations and management guidelines are covered.

About the Authors

Drew Provan Senior Lecturer in Haematology, Bart's and The London, Queen Mary's School of Medicine and Dentistry, University of London, UK

Charles R J Singer Consultant Haematologist, Royal United Hospital, Bath, UK

Trevor Baglin Consultant Haematologist, Addenbrookes NHS Trust, Cambridge, UK

Inderjeet Dokal Professor of Paediatrics, Barts and the London, School of Medicine and Dentistry, London, UK

Disclaimer: Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.

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